Stereoselective Synthesis of Fused Spiroindolines via Tandem Mannich/Intramolecular Aminal Formation

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• 作者：Juan Yang ; Xingang Xie ; Zhengshen Wang ; Ruoming Mei ; Huaiji Zheng ; Xiaolei Wang ; Ling Zhang ; Jing Qi ; Xuegong She
• 刊名：The Journal of Organic Chemistry
• 出版年：2013
• 出版时间：February 1, 2013
• 年：2013
• 卷：78
• 期：3
• 页码：1230-1235
• 全文大小：353K
• 年卷期：v.78,no.3(February 1, 2013)
• ISSN：1520-6904

文摘

A novel tandem Mannich/intramolecular aminal formation between tryptamines and salicylaldehydes was reported. This strategy provides a promising approach for the stereoselective synthesis of a range of complex fused spiroindolines, which bear a highly congested contiguous spiro quaternary center and two tertiary stereocenters, in a highly economical and effective fashion.