A N-(2-Aminophenyl)-5-(dimethylamino)-1-naphthalenesulfonic Amide (Ds-DAB) Based Fluorescent Chemosensor for Peroxynitrite

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• 作者：Ku-Kuei Lin ; Shou-Cheng Wu ; Kuang-Mei Hsu ; Chen-Hsiung Hung ; Wen-Feng Liaw ; Yun-Ming Wang
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：August 16, 2013
• 年：2013
• 卷：15
• 期：16
• 页码：4242-4245
• 全文大小：280K
• 年卷期：v.15,no.16(August 16, 2013)
• ISSN：1523-7052

文摘

A dansyl derivative (Ds-DAB) was prepared and used as a fluorescent probe for peroxynitrite (ONOO^{鈥?/sup>) detection. The results showed that the addition of peroxynitrite to the aqueous solution of Ds-DAB would result in obvious fluorescence enhancement. This probe is highly specific for peroxynitrite in aqueous solution, avoiding interference from other reactive oxygen species (ROS) and nitrogen species (RNS). The advantages of high selectivity, fast reaction rate, and peroxynitrite bioimaging render Ds-DAB suitable for peroxynitrite detection.}