Highly Efficient Chemoselective Synthesis of Polysubstituted Pyrroles via Isocyanide-Based Multicomponent Domino Reaction

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• 作者：Xiang Wang ; Xiao-Ping Xu ; Shun-Yi Wang ; Weiqun Zhou ; Shun-Jun Ji
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：August 16, 2013
• 年：2013
• 卷：15
• 期：16
• 页码：4246-4249
• 全文大小：262K
• 年卷期：v.15,no.16(August 16, 2013)
• ISSN：1523-7052

文摘

A multicomponent domino reaction for the chemoselective, catalyst-free synthesis of polysubstituted pyrroles from readily available isocyanides, primary or secondary amines, and gem-diactivated olefins has been developed. Structurally diverse pyrroles were obtained in moderate to good yields under mild conditions.