A Novel Chiral Bisphosphine-Thiourea Ligand for Asymmetric Hydrogenation of 尾,尾-Disubstituted Nitroalkenes

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• 作者：Qingyang Zhao ; Shengkun Li ; Kexuan Huang ; Rui Wang ; Xumu Zhang
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：August 2, 2013
• 年：2013
• 卷：15
• 期：15
• 页码：4014-4017
• 全文大小：267K
• 年卷期：v.15,no.15(August 2, 2013)
• ISSN：1523-7052

文摘

A novel chiral bisphosphine-thiourea ligand was developed and applied in the highly enantioselective hydrogenation of 尾,尾-disubstituted nitroalkenes (up to 99% yield and 99% ee). With low catalytic loading (0.25 mol %), 98% ee and 98% conversion were obtained. The thiourea group takes on an important role in this catalytic system.