Switching Photonic and Electrochemical Functions of a DNAzyme by DNA Machines

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• 作者：Xiaoqing Liu ; Angelica Niazov-Elkan ; Fuan Wang ; Itamar Willner
• 刊名：Nano Letters
• 出版年：2013
• 出版时间：January 9, 2013
• 年：2013
• 卷：13
• 期：1
• 页码：219-225
• 全文大小：408K
• 年卷期：v.13,no.1(January 9, 2013)
• ISSN：1530-6992

文摘

DNA nanostructures acting as DNA machines are described. Specifically, DNA 鈥渨alkers鈥?assembled on nucleic acid scaffolds and triggered by fuel/antifuel strands are activated in solution or on surfaces, for example, electrodes or semiconductor CdSe/ZnS quantum dots (QDs). The DNA machines led to the switchable formation or dissociation of the hemin/G-quadruplex DNAzyme on the DNA scaffolds. This enabled the chemiluminescence, chemiluminescence resonance energy transfer (CRET), electrochemical, or photoelectrochemical transduction of the switchable states of the different DNA machines.

Keywords:

DNA; walker; machine; chemiluminescence; quantum dots (QDs); nanotechnology