A Safe and Facile Route to Imidazole-1-sulfonyl Azide as a Diazotransfer Reagent

详细信息    查看全文

• 作者：Hui Ye ; Ruihua Liu ; Dongmei Li ; Yonghui Liu ; Haixin Yuan ; Weikang Guo ; Lifei Zhou ; Xuefeng Cao ; Hongqi Tian ; Jie Shen ; Peng George Wang
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：January 4, 2013
• 年：2013
• 卷：15
• 期：1
• 页码：18-21
• 全文大小：253K
• 年卷期：v.15,no.1(January 4, 2013)
• ISSN：1523-7052

文摘

A facile approach to the diazotransfer reagent of imidazole-1-sulfonyl azide was reported. The procedure was well optimized to clarify potential explosion risks. A high production yield as well as small batch variation was achieved even without careful pretreatment of reagents and solvents. HPLC and NMR methods to monitor the process were provided. These features made this protocol suitable for large scale preparation in academia and industry as well.