Novel 2-Aminobenzamides as Potential Orally Active Antithrombotic Agents

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• 作者：Amit Verma ; Rajani Giridhar ; Ashish Kanhed ; Anshuman Sinha ; Pratik Modh ; Mange R. Yadav
• 刊名：ACS Medicinal Chemistry Letters
• 出版年：2013
• 出版时间：January 10, 2013
• 年：2013
• 卷：4
• 期：1
• 页码：32-36
• 全文大小：265K
• 年卷期：v.4,no.1(January 10, 2013)
• ISSN：1948-5875

文摘

In an effort to develop potent antithrombotic agents, a series of novel 2-aminobenzamide derivatives were synthesized and screened for their in vivo antithrombotic activity. Among the 23 compounds tested, compound (8g) showed the most promising antithrombotic activity, which was comparable with clinically used aspirin or warfarin, but at variance with these standard drugs, 8g did not exhibit the increased bleeding time, suggesting its potential as a novel antithrombotic agent.

Keywords:

2-aminobenzamide; antithrombotic agents; ionic liquid; thromboembolic disorders; antiplatelet