Redox-Responsive, Core Cross-Linked Polyester Micelles

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• 作者：Zhonghai Zhang ; Lichen Yin ; Chunlai Tu ; Ziyuan Song ; Yanfeng Zhang ; Yunxiang Xu ; Rong Tong ; Qin Zhou ; Jie Ren ; Jianjun Cheng
• 刊名：ACS Macro Letters
• 出版年：2013
• 出版时间：January 15, 2013
• 年：2013
• 卷：2
• 期：1
• 页码：40-44
• 全文大小：261K
• 年卷期：v.2,no.1(January 15, 2013)
• ISSN：2161-1653

文摘

Monomethoxy poly(ethylene glycol)-b-poly(Tyr(alkynyl)-OCA), a biodegradable amphiphilic block copolymer, was synthesized by means of ring-opening polymerization of 5-(4-(prop-2-yn-1-yloxy)benzyl)-1,3-dioxolane-2,4-dione (Tyr(alkynyl)-OCA) and used to prepare core cross-linked polyester micelles via click chemistry. Core cross-linking not only improved the structural stability of the micelles, but also allowed controlled release of cargo molecules in response to the reducing reagent. This new class of core cross-linked micelles can potentially be used in controlled release and drug delivery applications.