Gold Nanorods Carrying Paclitaxel for Photothermal-Chemotherapy of Cancer

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• 作者：Fei Ren ; Saheel Bhana ; Derek D. Norman ; Jermaine Johnson ; Lijing Xu ; Daniel L. Baker ; Abby L. Parrill ; Xiaohua Huang
• 刊名：Bioconjugate Chemistry
• 出版年：2013
• 出版时间：March 20, 2013
• 年：2013
• 卷：24
• 期：3
• 页码：376-386
• 全文大小：536K
• 年卷期：v.24,no.3(March 20, 2013)
• ISSN：1520-4812

文摘

Nanotechnology-based photothermal therapy has emerged as a promising treatment for cancer during the past decade. However, heterogeneous laser heating and limited light penetration can lead to incomplete tumor cell eradication. Here, we developed a method to overcome these limitations by combining chemotherapy with photothermal therapy using paclitaxel-loaded gold nanorods. Paclitaxel was loaded to gold nanorods with high density (2.0 脳 10⁴ paclitaxel per gold nanorod) via nonspecific adsorption, followed by stabilization with poly(ethylene glycol) linked with 11-mercaptoundecanoic acid. Paclitaxel was entrapped in the hydrophobic pocket of the polymeric monolayer on the surface of gold nanorods, which allows direct cellular delivery of the hydrophobic drugs via the lipophilic plasma membrane. Highly efficient drug release was demonstrated in a cell membrane mimicking two-phase solution. Combined photothermal therapy and chemotherapy with the paclitaxel-loaded gold nanorods was shown to be highly effective in killing head and neck cancer cells and lung cancer cells, superior to photothermal therapy or chemotherapy alone due to a synergistic effect. The paclitaxel-gold nanorod enabled photothermal chemotherapy has the potential of preventing tumor reoccurrence and metastasis and may have an important impact on the treatment of head and neck cancer and other malignancies in the clinic.