An On-Chip, Multichannel Droplet Sorter Using Standing Surface Acoustic Waves

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• 作者：Sixing Li ; Xiaoyun Ding ; Feng Guo ; Yuchao Chen ; Michael Ian Lapsley ; Sz-Chin Steven Lin ; Lin Wang ; J. Philip McCoy ; Craig E. Cameron ; Tony Jun Huang
• 刊名：Analytical Chemistry
• 出版年：2013
• 出版时间：June 4, 2013
• 年：2013
• 卷：85
• 期：11
• 页码：5468-5474
• 全文大小：484K
• 年卷期：v.85,no.11(June 4, 2013)
• ISSN：1520-6882

文摘

The emerging field of droplet microfluidics requires effective on-chip handling and sorting of droplets. In this work, we demonstrate a microfluidic device that is capable of sorting picoliter water-in-oil droplets into multiple outputs using standing surface acoustic waves (SSAW). This device integrates a single-layer microfluidic channel with interdigital transducers (IDTs) to achieve on-chip droplet generation and sorting. Within the SSAW field, water-in-oil droplets experience an acoustic radiation force and are pushed toward the acoustic pressure node. As a result, by tuning the frequency of the SSAW excitation, the position of the pressure nodes can be changed and droplets can be sorted to different outlets at rates up to 222 droplets s^鈥?. With its advantages in simplicity, controllability, versatility, noninvasiveness, and capability to be integrated with other on-chip components such as droplet manipulation and optical detection units, the technique presented here could be valuable for the development of droplet-based micro total analysis systems (渭TAS).