A Ratiometric Near-Infrared Fluorescent Probe for Hydrazine and Its in Vivo Applications

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• 作者：Chong Hu ; Wen Sun ; Jianfang Cao ; Pan Gao ; Jingyun Wang ; Jiangli Fan ; Fengling Song ; Shiguo Sun ; Xiaojun Peng
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：August 2, 2013
• 年：2013
• 卷：15
• 期：15
• 页码：4022-4025
• 全文大小：256K
• 年卷期：v.15,no.15(August 2, 2013)
• ISSN：1523-7052

文摘

Based on modulation of the conjugated polymethine 蟺-electron system of a cyanine dye derivative, a ratiometric near-infared fluorescent probe (Cy7A) for hydrazine (N₂H₄) has been designed and synthesized. Cy7A can be selectively hydrazinolysized with great changes in its fluorescent excitation/emission profiles, which makes it possible to detect N₂H₄ in water samples and living cells and, for the first time, visualize N₂H₄ in living mice.