Antiproliferative and Hypoglycemic Cucurbitane-Type Glycosides from the Fruits of Momordica charantia

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• 作者：Ping-Chun Hsiao ; Chia-Ching Liaw ; Syh-Yuan Hwang ; Hui-Ling Cheng ; Li-Jie Zhang ; Chien-Chang Shen ; Feng-Lin Hsu ; Yao-Haur Kuo
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2013
• 出版时间：March 27, 2013
• 年：2013
• 卷：61
• 期：12
• 页码：2979-2986
• 全文大小：351K
• 年卷期：v.61,no.12(March 27, 2013)
• ISSN：1520-5118

文摘

This paper reports that bioassay-guided fractionations of EtOH extract of Momordica charantia fruits led to the isolation of 15 cucurbitane-type triterpene glycosides including 4 new compounds, kuguaosides A鈥揇 (1鈥?b>4), along with 11 known ones, charantoside A (5), momordicosides I (6), F₁ (7), F₂ (8), K (9), L (10), and U (11), goyaglycosides-b (12) and -d (13), 7尾,25-dihydroxycucurbita-5,23(E)-dien-19-al 3-O-尾-d-allopyranoside (14), and 25-hydroxy-5尾,19-epoxycucurbita-6,23-dien-19-on-3尾-ol 3-O-尾-d-glucopyranoside (15). Their structures were elucidated on the basis of spectroscopic analyses and chemical methods. This study also established the HPLC-ELSD fingerprinting profile of an antiproliferative fraction of which 11 main peaks were identified. Biological evaluation showed that several isolated cucurbitane-type triterpene glycosides had antiproliferative activities against MCF-7, WiDr, HEp-2, and Doay human tumor cell lines. In addition, compound 14 showed potent hypoglycemic activities by glucose uptake assay.

Keywords:

Momordica charantia; cucurbitane; triterpene glycosides; kuguaoside; antiproliferative activity; hypoglycemic activity