Anti-inflammatory Diterpenoids from Croton tonkinensis

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• 作者：Ping-Chung Kuo ; Mei-Lin Yang ; Tsong-Long Hwang ; Yuan-Yu Lai ; Yue-Chiun Li ; Tran Dinh Thang ; Tian-Shung Wu
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：February 22, 2013
• 年：2013
• 卷：76
• 期：2
• 页码：230-236
• 全文大小：259K
• 年卷期：v.76,no.2(February 22, 2013)
• ISSN：1520-6025

文摘

Phytochemical investigation of the methanolic extract of Croton tonkinensis afforded two known kauranes (1, 2), eight new ent-kauranes (3鈥?b>10), and 16 known ent-kaurane-type diterpenoids (12鈥?b>27). In addition, 30 known compounds were identified by comparison of their physical and spectroscopic data with reported data. Among the isolated compounds, ent-18-acetoxykaur-16-en-15-one (20) displayed the most significant inhibition of superoxide anion generation and elastase release.