Preventive Effects of Monascus on Androgen-Related Diseases: Androgenetic Alopecia, Benign Prostatic Hyperplasia, and Prostate Cancer

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• 作者：Hui-Wen Chiu ; Mei-Huei Chen ; Wen-Hung Fang ; Ching-Ming Hung ; Yen-Lin Chen ; Ming-Der Wu ; Gwo-Fang Yuan ; Ming-Jiuan Wu ; Ying-Jan Wang
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2013
• 出版时间：May 8, 2013
• 年：2013
• 卷：61
• 期：18
• 页码：4379-4386
• 全文大小：470K
• 年卷期：v.61,no.18(May 8, 2013)
• ISSN：1520-5118

文摘

Androgen-related diseases impair the well-being of many aging men. Unfortunately, the medications used to treat these diseases have many side effects. Therefore, there is a significant need for the development of novel drugs to treat androgen-related diseases. In this study, we investigated the effects of Monascus cursory extraction (M-CE) on androgen-related diseases, including androgenetic alopecia (AGA), benign prostatic hyperplasia (BPH) and prostate cancer. We found that M-CE suppressed baldness in male B6CBAF1/j mice. Furthermore, M-CE decreased PSA levels, indicating a protective effect of M-CE on testosterone-induced hyperplasia. M-CE also significantly decreased tumor volume and tumor incidence in an N-methyl-N-nitrosourea (MNU)/testosterone-induced rat prostate cancer model and markedly decreased dihydrotestosterone (DHT) but not testosterone. Additionally, PCNA expression was decreased in the prostate of rats treated with M-CE. These results suggest that M-CE could be a new potential therapeutic candidate for the treatment of androgen-related diseases.

Keywords:

Monascus; androgenetic alopecia; benign prostate hyperplasia; prostate cancer