Large-Scale Aqueous Synthesis of Fluorescent and Biocompatible Silicon Nanoparticles and Their Use as Highly Photostable Biological Probes

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• 作者：Yiling Zhong ; Fei Peng ; Feng Bao ; Siyi Wang ; Xiaoyuan Ji ; Liu Yang ; Yuanyuan Su ; Shuit-Tong Lee ; Yao He
• 刊名：The Journal of the American Chemical Society
• 出版年：2013
• 出版时间：June 5, 2013
• 年：2013
• 卷：135
• 期：22
• 页码：8350-8356
• 全文大小：478K
• 年卷期：v.135,no.22(June 5, 2013)
• ISSN：1520-5126

文摘

A large-scale synthetic strategy is developed for facile one-pot aqueous synthesis of silicon nanoparticles (SiNPs) yielding 0.1 g SiNPs of small sizes (2.2 nm) in 10 min. The as-prepared SiNPs feature strong fluorescence (photoluminescence quantum yield of 20鈥?5%), favorable biocompatibility, and robust photo- and pH-stability. Moreover, the SiNPs are naturally water dispersible, requiring no additional post-treatment. Such SiNPs can serve as highly photostable bioprobes and are superbly suitable for long-term immunofluorescent cellular imaging.