Rattle-Structured Multifunctional Nanotheranostics for Synergetic Chemo-/Radiotherapy and Simultaneous Magnetic/Luminescent Dual-Mode Imaging

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• 作者：Wenpei Fan ; Bo Shen ; Wenbo Bu ; Feng Chen ; Kuaile Zhao ; Shengjian Zhang ; Liangping Zhou ; Weijun Peng ; Qingfeng Xiao ; Huaiyong Xing ; Jianan Liu ; Dalong Ni ; Qianjun He ; Jianlin Shi
• 刊名：The Journal of the American Chemical Society
• 出版年：2013
• 出版时间：May 1, 2013
• 年：2013
• 卷：135
• 期：17
• 页码：6494-6503
• 全文大小：559K
• 年卷期：v.135,no.17(May 1, 2013)
• ISSN：1520-5126

文摘

Most hypoxic tumors are insensitive to radiation, which is a major obstacle in the development of conventional radiotherapy for tumor treatment. Some drugs, such as cisplatin (CDDP), have been extensively used both as an anticancer drug and clinically as a radiosensitizer to enhance radiotherapy. Herein, we develop rattle-structured multifunctional up-conversion core/porous silica shell nanotheranostics (UCSNs) for delivering CDDP to tumors for synergetic chemo-/radiotherapy by CDDP radiosensitization and magnetic/luminescent dual-mode imaging. UCSNs had a dynamic light scattering diameter of 79.1 nm and excellent water dispersity and stability. In vitro studies showed that CDDP loaded in UCSNs (UCSNs-CDDP) was more effective than free CDDP as a radiosensitizer. After injection, UCSNs-CDDP also demonstrated unambiguously enhanced radiotherapy efficacy in vivo. Our report aims at presenting a novel strategy in biomedical nanotechnology that allows simultaneous dual-mode imaging and localized therapy via synergetic chemo-/radiotherapy, which may achieve optimized therapeutic efficacy in cancer treatment.