Transition-Metal-Catalyzed Regeneration of Nicotinamide Coenzymes with Hydrogen1

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• 作者：Paul S. Wagenknecht ; Jonathan M. Penney ; and Robert T. Hembre
• 刊名：Organometallics
• 出版年：2003
• 出版时间：March 17, 2003
• 年：2003
• 卷：22
• 期：6
• 页码：1180 - 1182
• 全文大小：57K
• 年卷期：v.22,no.6(March 17, 2003)
• ISSN：1520-6041

文摘

The nicotinamide coenzymes consumed inalcohol dehydrogenase catalyzed enantioselective reduction of ketones are expensive and thus require recycling.We have demonstrated that ruthenium(II) and rhodium(III) complexes are effective catalysts for the reductionof nicotinamide coenzymes with hydrogen, under conditions that are appropriate for in situ coupling withenzymatic reductions.