Antioxidant Lignans and Chromone Glycosides from Eurya japonica

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• 作者：Li-Ming Yang Kuo ; Li-Jie Zhang ; Hung-Tse Huang ; Zhi-Hu Lin ; Chia-Ching Liaw ; Hui-Ling Cheng ; Kuo-Hsiung Lee ; Susan L. Morris-Natschke ; Yao-Haur Kuo ; Hsiu-O Ho
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：April 26, 2013
• 年：2013
• 卷：76
• 期：4
• 页码：580-587
• 全文大小：337K
• 年卷期：v.76,no.4(April 26, 2013)
• ISSN：1520-6025

文摘

Four new 8,8鈥?7,2鈥?lignans, (+)-ovafolinin B-9鈥?O-尾-d-glucopyranoside (1), (鈭?-ovafolinin B-9鈥?O-尾-d-glucopyranoside (2), (+)-ovafolinin E-9鈥?O-尾-d-glucopyranoside (3), and (鈭?-ovafolinin E-9鈥?O-尾-d-glucopyranoside (4), two neolignans, eusiderin N (5) and (7S,8R)-3,5,5鈥?trimethoxy-4鈥?7-epoxy-8,3鈥?neolignan-9,9鈥?diol-4-O-尾-d-xylopyranoside (6), and two new chromone glycosides, 5,7-dihydroxy-4H-chromen-4-one-3-O-尾-d-glucopyranoside (7) and 5,7-dihydroxy-4H-chromen-4-one-3-O-尾-d-xylopyranoside (8), together with 25 known compounds, were isolated from the stems of Eurya japonica. Structural elucidation of compounds 1鈥?b>8 was established by spectroscopic methods, especially 2D NMR techniques, electronic circular dichroism data, and comparison with reported data. The isolates were evaluated for antioxidant and anti-NO production activities. Compounds 1, 2, 12鈥?b>20, and 29 (ED₅₀ 23.40 渭M for 1) demonstrated potent antioxidant activity compared to the positive control 伪-tocopherol (ED₅₀ 27.21 渭M). On the other hand, compounds 1, 2, 7鈥?b>9, 12鈥?b>20, and 32 showed only weak anti-NO production activity when compared to the positive control quercetin.