Cytotoxic Polyketide Derivatives from the South China Sea Sponge Plakortis simplex

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• 作者：Jinrong Zhang ; Xuli Tang ; Jing Li ; Peifeng Li ; Nicole J. de Voogd ; Xiaoqin Ni ; Xiaojie Jin ; Xiaojun Yao ; Pinglin Li ; Guoqiang Li
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：April 26, 2013
• 年：2013
• 卷：76
• 期：4
• 页码：600-606
• 全文大小：339K
• 年卷期：v.76,no.4(April 26, 2013)
• ISSN：1520-6025

文摘

Five new polyketides, plakortoxides A (1) and B (2), simplextones C (3) and D (4), and plakorsin D (5), together with six known analogues (6鈥?b>11) were isolated from the South China Sea sponge Plakortis simplex. Their structures were identified by spectroscopic and chemical methods, including NMR, MS, and IR. Experimental and calculated ECD spectra and the modified Mosher鈥檚 method were used to determine the absolute configurations. Structurally, both plakortoxides A and B feature a butenolide coupled to an epoxide moiety, while simplextones C and D consist of 纬-butyrolactone and cyclopentane moieties, and plakorsin D is a furan acetic acid polyketide. The cytotoxic activities of the isolates were tested, and compounds 8, 10, and 11 showed potent cytotoxicity against both K562 and HeLa tumor cell lines with IC₅₀ values ranging from 0.8 to 5.3 渭M. Compound 3 showed significant inhibitory activity against c-Met kinase.