Imaging Mass Spectrometry-based Molecular Histology Differentiates Microscopically Identical and Heterogeneous Tumors

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• 作者：Emrys A. Jones ; Nicole Schmitz ; Cathelijn J. F. Waaijer ; Christian K. Frese ; Alexandra van Remoortere ; Ren茅 J. M. van Zeijl ; Albert J. R. Heck ; Pancras C. W. Hogendoorn ; Andr茅 M. Deelder ; A. F. Maarten Altelaar ; Judith V. M. G. Bov茅e ; Liam A. McDonnell
• 刊名：Journal of Proteome Research
• 出版年：2013
• 出版时间：April 5, 2013
• 年：2013
• 卷：12
• 期：4
• 页码：1847-1855
• 全文大小：602K
• 年卷期：v.12,no.4(April 5, 2013)
• ISSN：1535-3907

文摘

Many tumors display significant cellular heterogeneity as well as molecular heterogeneity. Sensitive biomarkers that differentiate between diagnostically challenging tumors must contend with this heterogeneity. Mass spectrometry-based molecular histology of a patient series of heterogeneous, microscopically identical bone tumors highlighted the tumor cell types that could be characterized by a single profile and led to the identification of specific peptides that differentiate between the tumors.

Keywords:

MALDI; imaging mass spectrometry; intratumor heterogeneity; chondrosarcoma; molecular histology