Casein Phosphopeptide-Biofunctionalized Graphene Biocomposite for Hydroxyapatite Biomimetic Mineralization

详细信息    查看全文

• 作者：Zengjie Fan ; Jinqing Wang ; Zhaofeng Wang ; Zhangpeng Li ; Yinong Qiu ; Honggang Wang ; Ye Xu ; Lengyuan Niu ; Peiwei Gong ; Shengrong Yang
• 刊名：The Journal of Physical Chemistry C
• 出版年：2013
• 出版时间：May 23, 2013
• 年：2013
• 卷：117
• 期：20
• 页码：10375-10382
• 全文大小：459K
• 年卷期：v.117,no.20(May 23, 2013)
• ISSN：1932-7455

文摘

Casein phosphopeptides (CPPs) with abundant phosphoserine clusters can mediate hydroxyapatite (HA) nucleation and growth. In this work, a new type of CPPs-biofuctionalized graphene composite was synthesized by amidation reaction between CPPs and carboxyalated graphene (CGO). When immersed in stimulated body fluid (1.5 脳 SBF) at 37 掳C for different periods, the CPPs layer on the composite facilitated efficient interaction between the CGO surface and mineral ions, which promoted HA nanoparticle formation and shortened mineralization time in comparison with pristine CGO. The synthesis of the composite mimicked the natural biomineralization of bone, demonstrating that CPPs can effectively improve the bioactivity of graphene and be useful for HA formation. The presented biocomposite may have potential biomedical applications in different areas.