Copolythiophene-Derived Colorimetric and Fluorometric Sensor for Lysophosphatidic Acid Based on Multipoint Interactions

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• 作者：Minhuan Lan ; Weimin Liu ; Ying Wang ; Jiechao Ge ; Jiasheng Wu ; Hongyan Zhang ; Jianhong Chen ; Wenjun Zhang ; Pengfei Wang
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2013
• 出版时间：March 27, 2013
• 年：2013
• 卷：5
• 期：6
• 页码：2283-2288
• 全文大小：352K
• 年卷期：v.5,no.6(March 27, 2013)
• ISSN：1944-8252

文摘

3-Phenylthiophene-based water-soluble copolythiophenes (CPT9) were designed for colorimetric and fluorometric detection of lysophosphatidic acid (LPA) based on electrostatic interaction, hydrophobic interaction, and hydrogen bonding. Other negatively charged species gave nearly no interference, and the detection limit reached to 0.6 渭M, which is below the requisite detection limits for LPA in human plasma samples. The appealing performance of CPT9 was demonstrated to originate from the multipoint interaction-induced conformational change of conjugated backbone and weakened electron transfer effect. To our best knowledge, this is the first polythiophene based optical sensor which displays emission peak red-shift followed with fluorescence enhancement.

Keywords:

conjugated polythiophene; biosensors; lysophosphatidic acid; ratiometric fluorescent; colorimetric; electron transfer