Multifunctional Fe3O4@P(St/MAA)@Chitosan@Au Core/Shell Nanoparticles for Dual Imaging and Photothermal Therapy

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• 作者：Xuandong Wang ; Huiyu Liu ; Dong Chen ; Xianwei Meng ; Tianlong Liu ; Changhui Fu ; Nanjing Hao ; Yanqi Zhang ; Xiaoli Wu ; Jun Ren ; Fangqiong Tang
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2013
• 出版时间：June 12, 2013
• 年：2013
• 卷：5
• 期：11
• 页码：4966-4971
• 全文大小：330K
• 年卷期：v.5,no.11(June 12, 2013)
• ISSN：1944-8252

文摘

Merging different components into a single nanoparticle can exhibit profound impact on various biomedical applications including diagnostics, imaging, and therapy. However, retaining the unique properties of each component after integration has proven to be a significant challenge. Our previous research demonstrated that gold nanoshells on polystyrene spheres have potential in photohermal therapy. Here, we report a facile and green strategy to synthesize a multifunctional nanocomposite with Fe₃O₄ core coated gold nanoshells as dual imaging probes and photothermal agents. The as-prepared nanoparticles exhibit well-defined structure and excellent physical properties such as magnetic and plasmonic activities. Therefore, they were applied as contrast agents in magnetic resonance imaging (MRI) and dark field imaging (DFI). Besides, we demonstrated their potential application in photothermal therapy. Moreover, the obtained multifunctional nanoparticles have shown excellent biocompatibility for their low cytotoxicity and hemolyticity.

Keywords:

magnetic cores; gold nanoshells; magnetic resonance imaging (MRI); dark field imaging (DFI); photothermal therapy