Toward the Next-Generation Nanomedicines: Design of Multifunctional Multiblock Polyurethanes for Effective Cancer Treatment

详细信息    查看全文

• 作者：Mingming Ding ; Nijia Song ; Xueling He ; Jiehua Li ; Lijuan Zhou ; Hong Tan ; Qiang Fu ; Qun Gu
• 刊名：ACS Nano
• 出版年：2013
• 出版时间：March 26, 2013
• 年：2013
• 卷：7
• 期：3
• 页码：1918-1928
• 全文大小：756K
• 年卷期：v.7,no.3(March 26, 2013)
• ISSN：1936-086X

文摘

Specific accumulation of therapeutics at tumor sites to improve in vivo biodistribution and therapeutic efficacy of anticancer drugs is a major challenge for cancer therapy. Herein, we demonstrate a new generation of intelligent nanosystem integrating multiple functionalities in a single carrier based on multifunctional multiblock polyurethane (MMPU). The smart nanocarriers equipped with stealth, active targeting, and internalizable properties can ferry paclitaxel selectively into tumor tissue, rapidly enter cancer cells, and controllably release their payload in response to an intracellular acidic environment, thus resulting in an improved biodistribution and excellent antitumor activity in vivo. Our work provides a facile and versatile approach for the design and fabrication of smart intracellular targeted nanovehicles for effective cancer treatment, and opens a new era in the development of biodegradable polyurethanes for next-generation nanodelivery systems.

Keywords:

intelligent; biodegradable multifunctional multiblock polyurethane; stimuli-responsive; nanomedicine; intracellular drug delivery; target; cancer therapy