Impossible or Merely Difficult? Two Grand Challenges from a Biologist鈥檚 Perspective

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• 作者：Bryan L. Roth
• 刊名：ACS Medicinal Chemistry Letters
• 出版年：2013
• 出版时间：March 14, 2013
• 年：2013
• 卷：4
• 期：3
• 页码：316-318
• 全文大小：172K
• 年卷期：v.4,no.3(March 14, 2013)
• ISSN：1948-5875

文摘

Here I propose two grand challenges for medicinal chemists: the deorphanization of orphan GPCRs via in silico methods and the design of multitarget drugs with enhanced safety and efficacy over current medications.

Keywords:

In silico screening; deorphanization; GPCR; obesity; polypharmacology