Generating Better Medicines for Cancer

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• 作者：Stuart S. Dunn ; James D. Byrne ; Jillian L. Perry ; Kai Chen ; Joseph M. DeSimone
• 刊名：ACS Macro Letters
• 出版年：2013
• 出版时间：May 21, 2013
• 年：2013
• 卷：2
• 期：5
• 页码：393-397
• 全文大小：346K
• 年卷期：v.2,no.5(May 21, 2013)
• ISSN：2161-1653

文摘

The complexity of tumor biology warrants tailored drug delivery for overcoming the major challenges faced by cancer therapies. The versatility of the PRINT (Particle Replication In Nonwetting Templates) process has enabled the preparation of shape- and size-specific particles with a wide range of chemical compositions and therapeutic cargos. Different particle matrices and drugs may be combined in a plug-and-play approach, such that physicochemical characteristics of delivery vectors may be optimized for biocompatibility, cargo stability, and release, circulation half-life, and efficacy. Thus, the engineering of particles for cancer therapy with specific biophysical behaviors and cellular responses has been demonstrated via the PRINT process.