Protective Effect of C70-Carboxyfullerene against Oxidative-Induced Stress on Postmitotic Muscle Cells

详细信息    查看全文

• 作者：Qiaoling Liu ; Junpeng Zheng ; Mirong Guan ; Xiaohong Fang ; Chunru Wang ; Chunying Shu
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2013
• 出版时间：May 22, 2013
• 年：2013
• 卷：5
• 期：10
• 页码：4328-4333
• 全文大小：300K
• 年卷期：v.5,no.10(May 22, 2013)
• ISSN：1944-8252

文摘

Satellite muscle cells play an important role in regeneration of skeletal muscle. However, they are particularly vulnerable to oxidative stress. Herein, we address our efforts on the cytoprotective activities of carboxyfullerenes with different cage size (C₆₀ vs C₇₀) and adduct number on postmitotic muscle cell (C2C12 cell). The correlation of the structural effect on the cytoprotective capability of carboxyfullerenes was evaluated. We find that quadri-malonic acid C₇₀ fullerene (QF₇₀) exhibits higher capability on protecting cells from oxidative-induced stress among these tested carboxyfullerenes. The accumulation of intracellular superoxide dismutase (SOD) is proposed to play an important role in their diverse antioxidative ability. Moreover, the pretreatment of QF₇₀ could also obviously enhance the viability of myotubes originated from oxidative-stressed C2C12 cells, which facilitates the future application of carboxyfullerenes in tissue engineering and nanomedicine.

Keywords:

carboxyfullerene; oxidative stress; chemical structure; cytoprotective capability; C2C12 cell