Visualizing Neurotransmitter Secretion at Individual Synapses

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• 作者：Dalibor Sames ; Matthew Dunn ; Richard J. Karpowicz ; Jr. ; David Sulzer
• 刊名：ACS Chemical Neuroscience
• 出版年：2013
• 出版时间：May 15, 2013
• 年：2013
• 卷：4
• 期：5
• 页码：648-651
• 全文大小：227K
• 年卷期：v.4,no.5(May 15, 2013)
• ISSN：1948-7193

文摘

To advance understanding of the brain, the ability to measure both nerve cell electrical spiking and chemical neurotransmission with high spatial resolution is required. In comparison to the development of voltage sensors and Ca²⁺ indicator dyes over the past several decades, high resolution imaging of neurotransmitter (NT) release at single synapses has not been possible. In this Viewpoint, we discuss two recent developments toward this goal, namely, the design of fluorescent false neurotransmitters (FFNs) and optical neurotransmitter sensors.

Keywords:

neurotransmitter release; fluorescent imaging; FFNs; optical tracers; neurotransmitter sensors; brain activity maps