A Novel Glucose/pH Responsive Low-Molecular-Weight Organogel of Easy Recycling

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• 作者：Chaoyu Zhou ; Wenxia Gao ; Kaiwen Yang ; Long Xu ; Jinchang Ding ; Jiuxi Chen ; Miaochang Liu ; Xiaobo Huang ; Shun Wang ; Huayue Wu
• 刊名：Langmuir
• 出版年：2013
• 出版时间：November 5, 2013
• 年：2013
• 卷：29
• 期：44
• 页码：13568-13575
• 全文大小：479K
• 年卷期：v.29,no.44(November 5, 2013)
• ISSN：1520-5827

文摘

A new phenylboronic acid based gelator was developed to prepare low-molecular-weight organogel (LMOG), which could interact with several solvents to assemble into a three-dimensional nanofiber network. ¹H NMR spectroscopy study suggests that the driving force for the gelation includes hydrogen bonding and 蟺鈥撓€ stacking. Evaluated by UV-spectroscopy, the gel showed a prompt initial response to glucose at low concentration of 0.012 mmol/mL, which is a critical concentration of venous plasma glucose for diabetes. Significantly, this organogel exhibits excellent sensitivity to glucose among seven sugars tested (i.e., mannitol, galactose, lactose, maltose, sucrose, and fructose). The proposed formation of hydrogen-bonded complexes during the glucose sensing was supported by our energy calculation. Meanwhile, this organogel exhibits pH-response. Importantly, this LMOG could be conveniently recycled and thus be reused.