Poly(iohexol) Nanoparticles As Contrast Agents for in Vivo X-ray Computed Tomography Imaging

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• 作者：Qian Yin ; Felix Y. Yap ; Lichen Yin ; Liang Ma ; Qin Zhou ; Lawrence W. Dobrucki ; Timothy M. Fan ; Ron C. Gaba ; Jianjun Cheng
• 刊名：Journal of the American Chemical Society
• 出版年：2013
• 出版时间：September 18, 2013
• 年：2013
• 卷：135
• 期：37
• 页码：13620-13623
• 全文大小：260K
• 年卷期：v.135,no.37(September 18, 2013)
• ISSN：1520-5126

文摘

Biocompatible poly(iohexol) nanoparticles, prepared through cross-linking of iohexol and hexamethylene diisocyanate followed by coprecipitation of the resulting cross-linked polymer with mPEG-polylactide, were utilized as contrast agents for in vivo X-ray computed tomography (CT) imaging. Compared to conventional small-molecule contrast agents, poly(iohexol) nanoparticles exhibited substantially protracted retention within the tumor bed and a 36-fold increase in CT contrast 4 h post injection, which makes it possible to acquire CT images with improved diagnosis accuracy over a broad time frame without multiple administrations.