Antiferromagnetic Iron Nanocolloids: A New Generation in Vivo T1聽MRI Contrast Agent

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• 作者：Yung-Kang Peng ; Chien-Liang Liu ; Hsieh-Chih Chen ; Shang-Wei Chou ; Wei-Hsuan Tseng ; Yu-Jui Tseng ; Chia-Cheng Kang ; Jong-Kai Hsiao ; Pi-Tai Chou
• 刊名：Journal of the American Chemical Society
• 出版年：2013
• 出版时间：December 11, 2013
• 年：2013
• 卷：135
• 期：49
• 页码：18621-18628
• 全文大小：508K
• 年卷期：v.135,no.49(December 11, 2013)
• ISSN：1520-5126

文摘

A novel T₁ agent, antiferromagnetic 伪-iron oxide-hydroxide (伪-FeOOH) nanocolloids with a diameter of 2鈥? nm, has been successfully prepared. These nanocolloids, together with a post synthetic strategy performed in mesoporous silica, are a great improvement over the low T₁-weighted contrast common in traditional magnetic silica nanocomposites. The intrinsic antiferromagnetic goethite (伪-FeOOH) shows very low magnetization (M_z) of 0.05 emu g^鈥? at H = 2 T at 300 K (0.0006 emu g^鈥? for FeOOH/WMSN-PEG), which is 2 orders of magnitude smaller than any current ultrasmall iron oxide NPs (>5 emu g^鈥?) reported to date, hence ensuring the low r₂ ( M_z) (7.64 mM^鈥? s^鈥?) and r₂/r₁ ratio (2.03) at 4.7 T. These biodegradable 伪-FeOOH nanocolloids also demonstrate excellent in vitro cellular imaging and in vivo MR vascular and urinary trace imaging capability with outstanding biocompatibility, which is exceptionally well secreted by the kidney and not the liver as with most nanoparticles, opening up a new avenue for designing powerful antiferromagnetic iron T₁ contrast agents.