Cu-Catalyzed Cross-Dehydrogenative Coupling Reactions of (Benzo)thiazoles with Cyclic Ethers

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• 作者：Zengyang Xie ; Yuping Cai ; Hongwen Hu ; Chen Lin ; Juli Jiang ; Zhaoxu Chen ; Leyong Wang ; Yi Pan
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：September 6, 2013
• 年：2013
• 卷：15
• 期：17
• 页码：4600-4603
• 全文大小：272K
• 年卷期：v.15,no.17(September 6, 2013)
• ISSN：1523-7052

文摘

Copper-catalyzed cross-dehydrogenative coupling (CDC) reactions of (benzo)thiazoles with cyclic ethers were developed under mild conditions. In particular, the formation of C鈥揅 bonds via the CDC reactions between non-benzo-fused azoles and ethers are reported for the first time. In addition, the acetals, known as the masked 2-thiazolecarboxaldehydes, could be successfully obtained by this CDC reaction. The preliminary mechanism and supportive DFT calculations are discussed as well.