Lancolides, Antiplatelet Aggregation Nortriterpenoids with Tricyclo[6.3.0.02,11]undecane-Bridged System from Schisandra lancifolia

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• 作者：Yi-Ming Shi ; Xin-Bo Wang ; Xiao-Nian Li ; Xiao Luo ; Zi-Ying Shen ; Yi-Ping Wang ; Wei-Lie Xiao ; Han-Dong Sun
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：October 4, 2013
• 年：2013
• 卷：15
• 期：19
• 页码：5068-5071
• 全文大小：291K
• 年卷期：v.15,no.19(October 4, 2013)
• ISSN：1523-7052

文摘

A new class of highly oxygenated Schisandra nortriterpenoids, lancolides A鈥揇 (1鈥?b>4), from Schisandra lancifolia, represents the first example of natural products that possess a tricyclo[6.3.0.0^2,11]undecane-bridged system. Their structures were elucidated by NMR spectra, X-ray diffraction, and quantum chemical calculations. Lancolides A (1) and D (4) had specific antiplatelet aggregation induced by platelet-activating factor (PAF).