Nivetetracyclates A and B: Novel Compounds Isolated from Streptomyces niveus

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• 作者：Caixia Chen ; Xueting Liu ; Wael M. Abdel-Mageed ; Hui Guo ; Weiyuan Hou ; Marcel Jaspars ; Li Li ; Feng Xie ; Biao Ren ; Qian Wang ; Huanqin Dai ; Fuhang Song ; Lixin Zhang
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：November 15, 2013
• 年：2013
• 卷：15
• 期：22
• 页码：5762-5765
• 全文大小：246K
• 年卷期：v.15,no.22(November 15, 2013)
• ISSN：1523-7052

文摘

A high-throughput screening of a microbial natural product library led to the discovery of two novel compounds named nivetetracyclates A and B (1 and 2), which were produced by Streptomyces niveus designated as LS2151. The backbone of the compounds contains a hydrotetracyclate not previously reported from a natural source. The structures of the compounds were elucidated by spectroscopic methods. The nivetetracyclates exhibited activity against human HeLa cells.