Ruthmycin, a New Tetracyclic Polyketide from Streptomyces sp. RM-4-15

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• 作者：Xiachang Wang ; Sherif I. Elshahawi ; Khaled A. Shaaban ; Lei Fang ; Larissa V. Ponomareva ; Yinan Zhang ; Gregory C. Copley ; James C. Hower ; Chang-Guo Zhan ; Madan K. Kharel ; Jon S. Thorson
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：January 17, 2014
• 年：2014
• 卷：16
• 期：2
• 页码：456-459
• 全文大小：228K
• ISSN：1523-7052

文摘

The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C₃ bridge and a corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer, and antifungal assays revealed ruthmycin to display moderate antifungal activity.