A Novel Water-Soluble Heptaplatin Analogue with Improved Antitumor Activity and Reduced Toxicity

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• 作者：Weiping Liu ; Xizhu Chen ; Qingsong Ye ; Yongping Xu ; Chengying Xie ; Mingjin Xie ; Qiaowen Chang ; Liguang Lou
• 刊名：Inorganic Chemistry
• 出版年：2011
• 出版时间：June 20, 2011
• 年：2011
• 卷：50
• 期：12
• 页码：5324-5326
• 全文大小：709K
• 年卷期：v.50,no.12(June 20, 2011)
• ISSN：1520-510X

文摘

A novel water-soluble heptaplatin analogue, cis-[(4R,5R)-4,5-bis-(aminomethyl)-2-isopropyl-1,3-dioxolane](3-hydroxy-1,1-cyclobutanedicarboxylato)platinum(II), has been synthesized and biologically evaluated. The complex shows more activity and less toxicity than its parent drug heptaplatin, exhibiting the great potential for further development.