Variability in PCB and OH-PCB Serum Levels in Children and Their Mothers in Urban and Rural U.S. Communities

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• 作者：Rachel F. Marek ; Peter S. Thorne ; Jeanne DeWall ; Keri C. Hornbuckle
• 刊名：Environmental Science & Technology
• 出版年：2014
• 出版时间：November 18, 2014
• 年：2014
• 卷：48
• 期：22
• 页码：13459-13467
• 全文大小：461K
• ISSN：1520-5851

文摘

Environmental exposures that affect accumulation of polychlorinated biphenyls (PCBs) in humans are complex and not fully understood. One challenge in linking environmental exposure to accumulation is determining variability of PCB concentrations in samples collected from the same person at different times. We hypothesized that PCBs in human blood serum are consistent from year to year in people who live in the same environment between sampling. We analyzed blood serum from children and their mothers from urban and rural U.S. communities (n = 200) for all 209 PCBs (median 鈭慞CBs = 45 ng/g lw) and 12 hydroxylated PCBs (median 鈭慜H-PCBs = 0.09 ng/g fw). A subset of these participants (n = 155) also had blood PCB and OH-PCB concentrations analyzed during the previous calendar year. Although many participants had similar levels of PCBs and OH-PCBs in their blood from one year to the next, some participants had surprisingly different levels. Year-to-year variability in 鈭慞CBs ranged from 鈭?7% to 567% and in 鈭慜H-PCBs ranged from 鈭?1 to 358% (5th鈥?5th percentile). This is the first study to report variability of all PCBs and major metabolites in two generations of people and suggests short-term exposures to PCBs may be a significant component of what is measured in human serum.