Analysis of Potential Migrants from Plastic Materials in Milk by Liquid Chromatography鈥揗ass Spectrometry with Liquid鈥揕iquid Extraction and Low-Temperature Purification

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• 作者：Zsolt Bodai ; B谩lint S谩muel Szab贸 ; M谩rton Nov谩k ; Susanne H谩mori ; Zolt谩n Nyiri ; Tam谩s Rikker ; Zsuzsanna Eke
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2014
• 出版时间：October 15, 2014
• 年：2014
• 卷：62
• 期：41
• 页码：10028-10037
• 全文大小：719K
• ISSN：1520-5118

文摘

A simple and fast analytical method was developed for the determination of six UV stabilizers (Cyasorb UV-1164, Tinuvin P, Tinuvin 234, Tinuvin 326, Tinuvin 327, and Tinuvin 1577) and five antioxidants (Irgafos 168, Irganox 1010, Irganox 3114, Irganox 3790, and Irganox 565) in milk. For sample preparation liquid鈥搇iquid extraction with low-temperature purification combined with centrifugation was used to remove fats, proteins, and sugars. After the cleanup step, the sample was analyzed with high-performance liquid chromatography鈥搕andem mass spectrometry (LC-MS/MS). External standard and matrix calibrations were tested. External calibration proved to be acceptable for Tinuvin P, Tinuvin 234, Tinuvin 326, Tinuvin 327, Irganox 3114, and Irganox 3790. The method was successfully validated with matrix calibration for all compounds. Method detection limits were between 0.25 and 10 渭g/kg. Accuracies ranged from 93 to 109%, and intraday precisions were <13%.

Keywords:

liquid鈭抣iquid extraction with low-temperature purification; LC-MS/MS; polymer additives; migration; antioxidants; UV stabilizers; milk