Hopping-Mediated Anion Transport through a Mannitol-Based Rosette Ion Channel

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• 作者：Tanmoy Saha ; Sathish Dasari ; Debanjan Tewari ; Annamalai Prathap ; Kana M. Sureshan ; Amal K. Bera ; Arnab Mukherjee ; Pinaki Talukdar
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：October 8, 2014
• 年：2014
• 卷：136
• 期：40
• 页码：14128-14135
• 全文大小：649K
• ISSN：1520-5126

文摘

Artificial anion selective ion channels with single-file multiple anion-recognition sites are rare. Here, we have designed, by hypothesis, a small molecule that self-organizes to form a barrel rosette ion channel in the lipid membrane environment. Being amphiphilic in nature, this molecule forms nanotubes through intermolecular hydrogen bond formation, while its hydrophobic counterpart is stabilized by hydrophobic interactions in the membrane. The anion selectivity of the channel was investigated by fluorescence-based vesicle assay and planar bilayer conductance measurements. The ion transport by a modified hopping mechanism was demonstrated by molecular dynamics simulation studies.