Solubility of Ibuprofen Sodium Dihydrate in Acetone + Water Mixtures: Experimental Measurement and Thermodynamic Modeling

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• 作者：Weiqiang Dun ; Songgu Wu ; Weiwei Tang ; Xuemei Wang ; Dengqiong Sun ; Shichao Du ; Junbo Gong
• 刊名：Journal of Chemical & Engineering Data
• 出版年：2014
• 出版时间：November 13, 2014
• 年：2014
• 卷：59
• 期：11
• 页码：3415-3421
• 全文大小：347K
• ISSN：1520-5134

文摘

The solubility of ibuprofen sodium dihydrate (ISD) in acetone + water mixtures was measured by the gravimetric method at temperatures ranging from (279.55 to 312.05) K. The measured solubilities were correlated by the modified Apelblat equation, the 位h (Buchowski) equation, the van鈥檛 Hoff model, the combined nearly ideal binary solvent/Redlich鈥揔ister (CNIBS/R-K) equation, and the general single model. The modified Apelblat equation was the best model for correlating the solubility of ISD, while the general single model fits the best for mixed solvents. The standard enthalpy, entropy, and Gibbs energy of the dissociation process of ISD were calculated by the van鈥檛 Hoff equation and the modified Apelblat model. In addition, there was a maximum value of solubility at a certain acetone mole fraction in the acetone + water mixture.