Limonoids from the Seeds of Swietenia macrophylla with Inhibitory Activity against Dengue Virus 2

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• 作者：Yuan-Bin Cheng ; Yi-Ting Chien ; Jin-Ching Lee ; Chin-Kai Tseng ; Hui-Chun Wang ; I-Wen Lo ; Yi-Hung Wu ; Sheng-Yang Wang ; Yang-Chang Wu ; Fang-Rong Chang
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：November 26, 2014
• 年：2014
• 卷：77
• 期：11
• 页码：2367-2374
• 全文大小：358K
• ISSN：1520-6025

文摘

Fractionation of an ethanol-soluble extract of the seeds of Swietenia macrophylla yielded six new limonoids, swielimonoids A鈥揊 (1鈥?b>6), along with 20 known compounds. Compounds 1 and 2, mexicanolide-type limonoids, were assigned with an 伪,尾-unsaturated 未-lactone moiety (ring D) and a C鈺怌 bond between C-8 and C-30. Compounds 3鈥?b>6 could be categorized as highly oxygenated phragmalin-type limonoids. The structures of these new compounds were elucidated through the interpretation of spectroscopic data. The antidengue virus 2 activities of the isolated components from S. macrophylla were investigated, and of 12 compounds subjected to bioassay, compounds 2 and 7鈥?b>10 were found to show inhibitory activity in the range 3.5 to 12.5 渭M. Among these, the new limonoid 2 exhibited significant antiviral activity (EC₅₀ = 7.2 卤 1.33 渭M) with a selectivity index (CC₅₀/EC₅₀) value of >27.7.