Notolutesins A鈥揓, Dolabrane-Type Diterpenoids from the Chinese Liverwort Notoscyphus lutescens

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• 作者：Song Wang ; Rui-Juan Li ; Rong-Xiu Zhu ; Xiao-Yan Hu ; Yan-Xia Guo ; Jin-Chuan Zhou ; Zhao-Min Lin ; Jiao-Zhen Zhang ; Jing-Yi Wu ; Ya-Qi Kang ; Susan L. Morris-Natschke ; Kuo-Hsiung Lee ; Hui-Qing Yuan ; Hong-Xiang Lou
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：September 26, 2014
• 年：2014
• 卷：77
• 期：9
• 页码：2081-2087
• 全文大小：335K
• ISSN：1520-6025

文摘

Ten new dolabrane-type diterpenoids, notolutesins A鈥揓 (1鈥?b>10), were isolated from the Chinese liverwort Notoscyphus lutescens, along with four known compounds. The structures of the new compounds were established on the basis of extensive spectroscopic data, and that of 1 was confirmed by single-crystal X-ray crystallography. The absolute configuration of 1 was determined by comparing its experimental and calculated electronic circular dichroism spectra. All of the isolates were evaluated for their cytotoxicity against a small panel of human cancer cell lines, and compound 1 exhibited an IC₅₀ value of 6.2 渭M against the PC3 human prostate cancer cell line.