Substituent-Controlled Selective Synthesis of N-Acyl 2-Aminothiazoles by Intramolecular Zwitterion-Mediated C鈥揘 Bond Cleavage

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• 作者：Yang Wang ; Fei Zhao ; Yue Chi ; Wen-Xiong Zhang ; Zhenfeng Xi
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：November 21, 2014
• 年：2014
• 卷：79
• 期：22
• 页码：11146-11154
• 全文大小：599K
• ISSN：1520-6904

文摘

The cleavage of C鈥揘 bonds is an interesting and challenging subject in modern organic synthesis. We have achieved the first zwitterion-controlled C鈥揘 bond cleavage in the MCR reaction among lithium alkynethiolates, bulky carbodiimides, and acid chlorides to construct N-acyl 2-aminothiazoles. This is a simple, highly efficient, and general method for the preparation of N-acyl 2-aminothiazoles with a broad range of substituents. The selective synthesis of N-acyl 2-aminothiazoles significantly depends on the steric hindrance of carbodiimides. The result is in striking contrast with our previous convergent reaction giving 5-acyl-2-iminothiazolines via 1,5-acyl migration. It is indeed interesting that the slight change of the substituents on the carbodiimides can completely switch the product structure. Experimental and theoretical results demonstrate the reason why the C鈥揘 bond cleavage in the present system is prior to the acyl migration. The intramolecular hydrogen relay via unprecedented Hofmann-type elimination is essential for this totally new zwitterion-controlled C鈥揘 bond cleavage.