Cyclohexane-Fused Octahydroquinolizine Alkaloids from Myrioneuron faberi with Activity against Hepatitis C Virus

详细信息    查看全文

• 作者：Ming-Ming Cao ; Yu Zhang ; Xiao-Hui Li ; Zong-Gen Peng ; Jian-Dong Jiang ; Yu-Cheng Gu ; Ying-Tong Di ; Xiao-Nian Li ; Duo-Zhi Chen ; Cheng-Feng Xia ; Hong-Ping He ; Shun-Lin Li ; Xiao-Jiang Hao
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：September 5, 2014
• 年：2014
• 卷：79
• 期：17
• 页码：7945-7950
• 全文大小：345K
• ISSN：1520-6904

文摘

Investigation of the alkaloids from Myrioneuron faberi, a plant unique to China, gave four pairs of enantiomers (1鈥?b>4). (卤)-尾-Myrifabral A (1) and (卤)-伪-myrifabral A (2) formed an inseparable mixture of anomers (cluster A), as did (卤)-尾-myrifabral B (3) and (卤)-伪-myrifabral B (4) (cluster B). Their structures were determined by X-ray diffraction and NMR analysis. Compounds 1鈥?b>4 possessed novel cyclohexane-fused octahydroquinolizine skeletons and represent the first quinolizidine alkaloids from the genus Myrioneuron. The epimers of cluster A (1 and 2) were modified and separated. In vitro, clusters A and B and their derivatives inhibited replication of hepatitis C virus (HCV, IC₅₀ 0.9 to 4.7 渭M) with cytotoxicity lower than that of telaprevir.