Uniform Core鈥揝hell Photonic Crystal Microbeads as Microcarriers for Optical Encoding

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• 作者：Xiaolu Jia ; Yuandu Hu ; Ke Wang ; Ruijing Liang ; Jingyi Li ; Jianying Wang ; Jintao Zhu
• 刊名：Langmuir
• 出版年：2014
• 出版时间：October 14, 2014
• 年：2014
• 卷：30
• 期：40
• 页码：11883-11889
• 全文大小：436K
• ISSN：1520-5827

文摘

We demonstrate a rapid and robust method to fabricate uniform core鈥搒hell photonic crystal (PC) microbeads by the microfluidic and centrifugation鈥搑edispersion technique. Colored crystalline colloidal arrays (CCAs) were first prepared through centrifugation鈥搑edispersion approach by self-assembly of polystyrene鈥損oly(N-isopropylacrylamide) (PS鈥揚NIPAm) core/shell nanoparticles (NPs). Different from the conventional NPs (e.g., charged PS or PNIPAm NPs), PS鈥揚NIPAm NPs could easily self-assemble into well-ordered CCAs by only one purification step without laborious pretreatment (e.g., dialysis or ion exchange) or slow solvent-evaporation process. The CCAs is then encapsulated into a transparent polymer shell with functional groups (e.g., copolymer of ETPTA and butyl acrylate (BA)), triggering the formation of core鈥搒hell PC microbeads which can be used as optical encoding microcarriers. Importantly, this technique allows us to produce core鈥搒hell PC microbeads in a rapid and robust way, and the optical reflections of the PC microbeads appear highly stable to various external stimuli (e.g., temperature, pH value, and ionic strength) relying on the features of the CCAs core and protection of the polymer shell. Moreover, various probe biomolecules (e.g., proteins, antibodies, and so on) can be easily linked on the surface of the core鈥搒hell PC microbeads owing to the hydrophilic modification induced by the hydrolysis of BA on the microbead surface, enabling the multiplex biomolecular detection.