Histidine-Derived Nontoxic Nitrogen-Doped Carbon Dots for Sensing and Bioimaging Applications

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• 作者：He Huang ; Chunguang Li ; Shoujun Zhu ; Hailong Wang ; Cailing Chen ; Zhaorui Wang ; Tianyu Bai ; Zhan Shi ; Shouhua Feng
• 刊名：Langmuir
• 出版年：2014
• 出版时间：November 18, 2014
• 年：2014
• 卷：30
• 期：45
• 页码：13542-13548
• 全文大小：461K
• ISSN：1520-5827

文摘

Nitrogen-doped (N-doped) photoluminescent carbon dots (CDs) were prepared by a one-pot microwave-assisted hydrothermal treatment using histidine as the sole carbon source in the absence of acid, alkali, or metal ions. With a diameter of 2鈥? nm, the synthesized CDs had apparent lattice fringes and exhibited an excitation-dependent photoluminescent behavior. The CDs were highly yielded, well-dispersed in aqueous solution, and showed high photostability in the solutions of a wide range of pH and salinity. They were used as probes to identify the presence of Fe³⁺ ions with a detection limit of 10 nM. With confirmed nontoxicity, these CDs could enter the cancer cells, indicating a practical potential for cellular imaging and labeling.