Sub-10 nm Monoclinic Gd2O3:Eu3+ Nanoparticles as Dual-Modal Nanoprobes for Magnetic Resonance and Fluorescence Imaging

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• 作者：Jun Liu ; Xiumei Tian ; Ningqi Luo ; Chuan Yang ; Jun Xiao ; Yuanzhi Shao ; Xiaoming Chen ; Guowei Yang ; Dihu Chen ; Li Li
• 刊名：Langmuir
• 出版年：2014
• 出版时间：November 4, 2014
• 年：2014
• 卷：30
• 期：43
• 页码：13005-13013
• 全文大小：695K
• ISSN：1520-5827

文摘

Monoclinic Gd₂O₃:Eu³⁺ nanoparticles (NPs) possess favorable magnetic and optical properties for biomedical application. However, how to obtain small enough NPs still remains a challenge. Here we combined the standard solid-state reaction with the laser ablation in liquids (LAL) technique to fabricate sub-10 nm monoclinic Gd₂O₃:Eu³⁺ NPs and explained their formation mechanism. The obtained Gd₂O₃:Eu³⁺ NPs exhibit bright red fluorescence emission and can be successfully used as fluorescence probe for cells imaging. In vitro and in vivo magnetic resonance imaging (MRI) studies show that the product can also serve as MRI good contrast agent. Then, we systematically investigated the nanotoxicity including cell viability, apoptosis in vitro, as well as the immunotoxicity and pharmacokinetics assays in vivo. This investigation provides a platform for the fabrication of ultrafine monoclinic Gd₂O₃:Eu³⁺ NPs and evaluation of their efficiency and safety in preclinical application.