Cu-Catalyzed Ring Opening Reaction of 2H-Azirines with Terminal Alkynes: An Easy Access to 3-Alkynylated Pyrroles

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• 作者：Tengfei Li ; Xiaoyi Xin ; Chunxiang Wang ; Dongping Wang ; Fan Wu ; Xincheng Li ; Boshun Wan
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：September 19, 2014
• 年：2014
• 卷：16
• 期：18
• 页码：4806-4809
• 全文大小：342K
• ISSN：1523-7052

文摘

A highly efficient Cu-catalyzed ring expansion reaction of 2H-azirines with terminal alkynes has been developed. This transformation provides a powerful method for the synthesis of 3-alkynyl polysubstituted pyrroles under mild conditions in good yields. The direct transformation process, specific selectivity, and good tolerance to a variety of substituents make it an alternative approach to the reported protocols.