Palladium-Catalyzed Aerobic Oxidative C鈥揌 Olefination with Removable 1,2,3-Triazole Directing Group

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• 作者：Xiaohan Ye ; Xiaodong Shi
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：September 5, 2014
• 年：2014
• 卷：16
• 期：17
• 页码：4448-4451
• 全文大小：429K
• ISSN：1523-7052

文摘

Ortho-olefination of arenes was achieved with removable 1,2,3-triazole auxiliary through Pd-catalyzed C鈥揌 activation. Excellent yields were received even when molecular O₂ (1 atm) was used as the terminal oxidant. Other heterocyclic directing groups, such as pyridine and quinoline, gave poor reactivity under this aerobic oxidative condition, which highlighted the unique reactivity of triazole in promoting directed C鈥揌 activation.