Solvent-Controlled Switchable C鈥揌 Alkenylation of 4-Aryl-1H-pyrrole-3-carboxylates: Application to the Total Synthesis of (卤)-Rhazinilam

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• 作者：Youla Su ; Haipin Zhou ; Jiaxuan Chen ; Jinyi Xu ; Xiaoming Wu ; Aijun Lin ; Hequan Yao
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：September 19, 2014
• 年：2014
• 卷：16
• 期：18
• 页码：4884-4887
• 全文大小：426K
• ISSN：1523-7052

文摘

A solvent-controlled switchable C鈥揌 alkenylation of 4-aryl-1H-pyrrole-3-carboxylates via a Pd(OAc)₂ catalyzed oxidative Heck reaction was first realized. The corresponding C2 and C5 alkenylation products were obtained in good yields with high regioselectivities, respectively. The selective C5-alkenylation was successfully applied to the total synthesis of (卤)-rhazinilam.